Hamza Lab

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PUBLICATIONS

Publications

Selected Publications

Google Scholar
NCBI Bibliography

Key publications

2019

Hemozoin produced by mammals confers heme tolerance.

[1][2]Pek RH, Yuan X, Rietzschel N, Zhang J, Jackson LK, Nishibori E, Ribeiro A, Simmons WR, Jagadeesh J, Sugimoto H, Alam MZ, Garrett LJ, Haldar M, Ralle M, Phillips J, Bodine D, Hamza I.

  • eLife, 2019; 8:e49503 (eLife Digest).

2017

Inter-organ signaling by HRG-7 promotes systemic heme homeostasis.

[3][4]Sinclair J, Pinter K, Samuel T, Beardsley S, Yuan X, Zhang J, Meng K, Yun S, Krause M, and Hamza I.

  • Nature Cell Biol. 2017;19:799-807.

2016

Regulation of intracellular heme trafficking revealed by subcellular reporters.

Yuan X, Rietzschel N, Kwon H, Nuno Da Silva ABW, Hanna DA, Phillips J, Raven E, Reddi AR and Hamza I.

  • Proc Natl Acad Sci, 2016; 113:E5144-5152.

2014

Control of metazoan heme homeostasis by a conserved multidrug resistance protein.

Korolnek T, Zhang J, Beardsley S, Scheffer GL, Hamza I.

  • Cell Metab. 2014;19:1008-1019.

2013

HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.

[5] White C, Yuan X, Schmidt PJ, Bresciani E, Samuel TK, Campagna D, Hall C, Bishop K, Calicchio ML, Lapierre A, Ward DM, Liu P, Fleming MD and Hamza I.

  • Cell Metab. 2013; 17: 261-270.

2011

An intercellular heme trafficking protein delivers maternal heme to the embryo during development in C. elegans.

[6] [7] [8] Chen C, Samuel TK, Sinclair J, Dailey H and Hamza I.

  • Cell. 2011; 145:720-731.

2008

Heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.

[9] [10] [11] Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M and Hamza I.

  • Nature 2008; 453: 1127-1131 (Epub Apr 16, 2008).

Selected reviews

  • Chambers IG, Willoughby MM, Hamza I, Reddi AR. One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers. Biochim Biophys Acta Mol Cell Res 2021, 1868(1):118881.
  • Soares MP and Hamza I. Macrophages and iron metabolism. Immunity 2016 Mar 15;44(3):492-504.
  • Korolnek T and Hamza I. Macrophages and iron trafficking at the birth and death of red cells. Blood. 2015 May 7;125(19):2893-2897. Epub 2015 Mar 16.
  • Hamza I and Dailey H. One ring to rule them all: Trafficking of heme and heme synthesis intermediates in eukaryotes. Biochim Biophys Acta- Molecular Cell Research. 2012;1823:1617-1632.
  • Severance S and Hamza I. Trafficking of Heme and Porphyrins in Metazoa. Chem. Rev. 2009; 109:4596-4616.

Iqbal Hamza, Ph.D. Professor

Dept. of Pediatrics, Center for Blood Oxygen Transport and Hemostasis (CBOTH)   
Dept. of Animal & Avian Sciences (Joint appointment with UMD)   
Biological Sciences Graduate Program (Member)

About Dr. Hamza

University of Maryland School of Medicine   
670 West Baltimore St
8175 HSFIII, CBOTH   
Baltimore, MD 21201   
Email: ihamza@som.umaryland.edu   
Phone: 410-706-4533

University of Maryland   
8127 Regents Drive
2125 Animal Sciences Center   
College Park, MD 20742   
Email: hamza@umd.edu   
Phone: 310-405-0649

[1] Highlighted in eLife Digest

[2] Highlighted in Press releases:
https://www.sciencedaily.com/releases/2019/10/191001110822.htm

[3] Highlighted in Press releases:
https://www.sciencedaily.com/releases/2017/06/170605121303.htm

[4] News & Views: Inter-organ regulation of haem homeostasis. Pitt JN and Kaeberlein M. Nat Cell Biol. 2017 Jun 29;19:756-758.

[5] Highlighted in Press releases:
http://www.sciencedaily.com/releases/2013/02/130205131752.htm

[6] Highlighted in Press releases:
http://www.sciencedaily.com/releases/2011/05/110526122909.htm
and
http://www.futurity.org/health-medicine/from-worms-clues-to-how-iron-moves/

[7] Recommended by the Faculty of 1000 Biology:
http://f1000.com/11215956
; F=6

[8] Research Highlight: Intercellular trafficking: Heme to go. Nat Chem Biol 2011; 7:496–497

[9] Modern Marvels: Iron, History Channel, Aug 14, 2008

[10] Highlighted by United Press International, Worms help in iron deficiency research, April 16, 2008:
http://www.sciencedaily.com/releases/2008/04/080416140912.htm

[11] Recommended by the Faculty of 1000 Biology:
http://f1000.com/1105036
; F=9

  1. Belot A, Rock A, Dutt S, Haemmerle G, Maros A, Yuan X, Otsuru S, Bodine D, Hamza I. A cell-nonautonomous heme acquisition pathway enables erythroid hemoglobinization under stress. Science 2026 (in revision).
  2. Dumetz F, Watson KJ, Perry M, Bromley RE, Shome AR, Dunning Hotopp JC, Hamza I, Serre D. The UTRs of Leishmania donovani vary in length and are enriched in potential regulatory structures. PLoS Pathog. 2026 (in revision).
  3. Lee JK, He Y, Flores SR, Woloshun RR, Wang X, Shine JS, Ebea-Ugwuanyi PO, Sriram S, Fraga M, Zhu S, Yu Y, Hamza I, Collins JF. Development of rat and mouse models of heme-iron absorption. JCI Insight. 2025 Jun 9;10(11):e184742. doi: 10.1172/jci.insight.184742. eCollection 2025 Jun 9. [PMID: 40485584]
  4. Perry M, Hamza I. Heme and immunity: The heme oxygenase dichotomy. J Inorg Biochem. 2025 Jun;267:112844. doi: 10.1016/j.jinorgbio.2025.112844. Epub 2025 Feb 6. [PMID: 39978176]
  5. Stockley JH, Vaquie AM, Xu Z, Bartels B, Holmqvist S, Gunter S, Lam G, Yamamoto D, Pek RH, Chambers IG, Rock AS, Hill M, Zhao C, Dillon S, Franklin RJM, O’Connor R, Bodine DM, Hamza I, Rowitch DH. Oligodendrocyte Slc48a1 (Hrg1) encodes a functional heme transporter required for myelin integrity. Glia 2025 Feb;73(2):399-421. doi: 10.1002/glia.24641. Epub 2024 Nov 6. [PMID: 39501820].
  6. Belot A, Puy H, Hamza I, Bonkovsky HL. Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy. Liver Int. 2024 Jun 18. doi: 10.1111/liv.15965. [PMID: 38888238]
  7. Hopp MT, Vaidya SM, Grimmig KM, Strudthoff LJ, Clauser JC, Yuan X, Singh S, Müller J, Oldenburg J, Hamza I, Imhof D. Quantitative analysis of heme and hemoglobin for the detection of intravascular hemolysis. Anal Chim Acta. 2024 Jul 11;1312:342766. doi: 10.1016/j.aca.2024.342766. Epub 2024 May 21.
  8. Chen C and Hamza I. Notes from the Underground: Heme Homeostasis in C. elegans. Biomolecules. 2023 Jul 19;13(7):1149. doi: 10.3390/biom13071149.
  9. Sun F, Zhao Z, Willoughby MM, Shen S, Zhou Y, Shao Y, Kang J, Chen Y, Chen M, Yuan X, Hamza I, Reddi AR, Chen C. HRG-9 homologues regulate haem trafficking from haem-enriched compartments. Nature 2022 610(7933):768-774.
  10. Dutt S, Hamza I, Bartnikas TB. Molecular mechanisms of iron and heme metabolism.  Annu Rev Nutr. 2022 May 4. doi: 10.1146/annurev-nutr-062320-112625.
  11. Chambers I, Kumar P, Lichtenberg J, Wang P, Yu J, Phillips J, Kane MA, Bodine D, Hamza I. MRP5 and MRP9 Play a Concerted Role in Male Reproduction and Mitochondrial Function. Proc Natl Acad Sci U S A 2022, 119(6).
  12. Hanna DA, Moore CM, Liu L, Yuan X, Dominic IM, Fleischhacker AS, Hamza I, Ragsdale SW, Reddi AR. Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells. J Biol Chem 2022, 298(2):101549.
  13. Simmons WR, Wain L, Toker J, Jagadeesh J, Garrett LJ, Pek RH, Hamza I, Bodine DM. Normal Iron Homeostasis Requires the Transporter SLC48A1 for Efficient Heme-Iron Recycling in Mammals. Front Genome Ed 2020, 2:8.
  14. Bergmann A, Floyd K, Key M, Dameron C, Rees KC, Thornton LB, Whitehead DC, Hamza I, Dou Z. Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection. PLoS Pathog. 2020 May 14;16(5):e1008499. doi: 0.1371/journal.ppat.1008499.
  15. Laranjeira-Silva MF, Hamza I and Pérez-Victoria JM. Iron and heme metabolism at the Leishmania-host interface.  Trends Parasitol. 2020 Mar;36(3):279-289.XXX
  16. Wißbrock A, Goradia NB, Kumar A, Paul George AA, Kühl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Krönke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschläger O, Imhof D. Structural insights into heme binding to IL-36α proinflammatory cytokine. Sci Rep. 2019 Nov 15;9(1):16893. doi: 10.1038/s41598-019-53231-0.
  17. Zhang J and Hamza I. Zebrafish as a model system to delineate the role of heme and iron metabolism during erythropoiesis.  Mol Genet Metab. 2018 Dec 24. pii: S1096-7192(18)30626-7.XXX
  18. Zhang J, Chambers I, Yun S, Phillips J, Krause M, Hamza I.  Hrg1 promotes heme-iron recycling during hemolysis in the zebrafish kidney.  PLoS Genet. 2018 Sep 24;14(9):e1007665. doi: 10.1371/journal.pgen.1007665. eCollection 2018 Sep.
  19. Ganasen M, Togashi H, Takeda H, Asakura H, Tosha T, Yamashita K, Hirata K, Nariai Y, Urano T, Yuan X, Hamza I, Mauk AG, Shiro Y, Sugimoto H, Sawai H.  Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.  Commun Biol. 2018 Aug 17;1:120. doi: 10.1038/s42003-018-0121-8. eCollection 2018.
  20. Laranjeira-Silva MF, Wang W , Samuel TK , Maeda FY , Michailowsky V, Hamza I, Liu Z, and Andrews NW. A MFS-like plasma membrane transporter promotes Leishmania virulence by protecting the parasites from iron toxicity. PLoS Pathog. 2018 Jun 15;14(6):e1007140. doi: 10.1371/journal.ppat.1007140. [Epub ahead of print]
  21. Yuan X, Hamza I. Cys links heme: Stereo-orientation of heme transfer in cytochrome c biogenesis. J Mol Biol. 2018 Mar 3.
  22. Chen AJ, Yuan X, Li J, Dong P, Hamza I, Cheng JX. Label-Free Imaging of Heme Dynamics in Living Organisms by Transient Absorption Microscopy. Anal Chem. 2018 Mar 6;90(5):3395-3401
  23. Gouveia Z, Carlos AR, Yuan X, Aires-da-Silva F, Stocker R, Maghzal GJ, Leal SS, Gomes CM, Todorovic S, Iranzo O, Ramos S, Santos AC, Hamza I, Gonçalves J, Soares MP.  Characterization of plasma labile heme in hemolytic conditions.  FEBS J. 2017 Aug 7. doi: 10.1111/febs.14192.
  24. Staroń R, Lipiński P, Lenartowicz M, Bednarz A, Gajowiak A, Smuda E, Krzeptowski W, Pieszka M, Korolonek T, Hamza I, Swinkels DW, Van Swelm RPL, Starzyński RR. Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption.  PLoS One. 2017;12:e0181117.
  25. Sinclair J, Pinter K, Samuel T, Beardsley S, Yuan X, Zhang J, Meng K, Yun S, Krause M, and Hamza I.  Inter-organ signaling by HRG-7 promotes systemic heme homeostasis Nature Cell Biol. 2017;19:799-807. Download PDF
  26. Yuan X, Rietzschel N, Kwon H, Nuno Da Silva ABW, Hanna DA, Phillips J, Raven E, Reddi AR and Hamza I. Regulation of intracellular heme trafficking revealed by subcellular reporters.  Proc Natl Acad Sci, 2016. Download PDF
  27. Hanna DA, Harvey RM, Martinez-Guzman, Yuan X, Chandrasekharan B, Raju G, Outten FW, Hamza I, and Reddi AR.  Heme Dynamics and Speciation Revealed by Genetically Encoded Fluorescent Heme Sensors.  Proc Natl Acad Sci, 2016;113:7539-7544. Download PDF
  28. Luck AN, Yuan X, Voronin D, Slatko BE, Hamza I, and Foster JM.  Heme Acquisition in the Parasitic Filarial Nematode, Brugia malayi. FASEB J. 2016 Jun 30. pii: fj.201600603R. [Epub ahead of print] Download PDF
  29. Reddi AR and Hamza I.  Heme mobilization in animals: A metallolipid’s journey.  Acc Chem Res. 2016;49:1104-1110. Download PDF
  30. Soares MP and Hamza I.  Macrophages and iron metabolism.  Immunity 2016 Mar 15;44(3):492-504. Download PDF
  31. Marciano O, Moskovitz Y, Hamza I, Ruthstein S.  Histidine residues are important for preserving the structure and heme coordination site of the C. elegans HRG-3 heme trafficking protein. J Biol Inorg Chem. 2015 Dec;20(8):1253-61.Download PDF
  32. Renberg R, Yuan X, Samuel TK, Miguel DC, Hamza I, Andrews NW and Flannery AR. The heme transport capacity of LHR1 determines the extent of virulence in Leishmania amazonensis.  PLoS Negl Trop Dis. 2015 May 22;9(5):e0003804. Download PDF
  33. Sinclair, JW and Hamza I.  Lessons from bloodless worms: Heme homeostasis in C. elegans.  Biometals. 2015; 28:481-489. Download PDF
  34. Korolnek T and Hamza I.  Macrophages and iron trafficking at the birth and death of red cells.  Blood. 2015;125:2893-2897. Download PDF
  35. Samuel TK, Sinclair JW, Pinter KL, and Hamza I. Culturing Caenorhabditis elegans in Axenic Liquid Media and Creation of Transgenic Worms by Microparticle Bombardment. J Vis Exp. 2014 Aug 2;(90). doi: 10.3791/51796. Download PDF
  36. Korolnek T and Hamza I. Like Iron in the Blood of the People: The Requirement for Heme Trafficking in Iron Metabolism. Front Pharmacol. 2014 Jun 4;5:126. eCollection 2014. Download PDF
  37. Korolnek T, Zhang J, Beardsley S, Scheffer GL, Hamza I. Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Cell Metab. 2014;19:1008-1019. Download PDF
  38. Yuan X, Fleming MD and Hamza I. Heme transport and erythropoiesis. Curr Opin Chem Biol. 2013 Apr;17(2):204-211 (Cover Illustration). Download PDF
  39. White C, Yuan X, Schmidt PJ, Bresciani E, Samuel TK, Campagna D, Hall C, Bishop K, Calicchio ML, Lapierre A, Ward DM, Liu P, Fleming MD and Hamza I. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013; 17: 261-270. Download PDF
    Highlighted by Science Daily, Protein that allows safe recycling of iron from old red blood cells identified.
  40. Hamza I and Dailey H. Porphyrin and Heme Trafficking in Metazoans. In: Handbook of Porphyrin Science with Applications to Chemistry, Physics, Materials Science, Engineering, Biology and Medicine. Edited by Kadish KM, Smith KM, Guilard R, Vol.26: Heme Biochemistry: Guest Editor: Gloria C. Ferreira. World Scientific Publishing Co.; 2013. Download PDF
  41. Fleming MD and Hamza I. Mitochondrial heme: an exit strategy at last. J Clin Invest. 2012; 122:4328-4330. Download PDF
  42. Hamza I and Dailey H. One ring to rule them all: Trafficking of heme and heme synthesis intermediates in eukaryotes. Biochim Biophys Acta. 2012;1823:1617-1632. Download PDF
  43. Huynh C, Yuan X, Miguel DC, Renberg R, Protchenko O, Philpott CC, Hamza I and Andrews NW. Heme uptake by Leishmania amazonensis is mediated by the transmembrane protein LHR1. PLoS Pathog 2012; 8: e1002795. Download PDF
  44. Chen C, Samuel TK, Krause M, Dailey HA, and Hamza I. Heme utilization in the Caenorhabditis elegans hypodermal cells is facilitated by Heme Responsive Gene-2. J Biol Chem. 2012; 287:9601-12. Epub 2012 Feb 2. Download PDF
  45. Yuan X, Protchenko O, Philpott CC, and Hamza I. Topologically conserved residues direct heme transport in HRG-1-related proteins. J Biol Chem. 2012;287:4914-4924. Epub 2011 Dec 15. Download PDF
  46. Chen C, Samuel TK, Sinclair J, Dailey H and Hamza I. An intercellular heme trafficking protein delivers maternal heme to the embryo during development in C. elegans. Cell. 2011; 145:720-731. Download PDF;
    Highlighted by Science Daily, Iron Ferrying Protein May be ‘Universal Achillis Heel’ for Parasitic Worms.
  47. Severance S, Chen C, Hamza I. Eukaryotic Heme Trafficking. In: Handbook of Porphyrin Science. Edited by Kadish KM, Smith KM, Guilard R, vol. 15: Biochemistry of Tetrapyrroles: World Scientific Publishing Co.; 2011: 1-48. Download PDF
  48. Sinclair J and Hamza I. A novel heme response element mediates transcriptional regulation in Caenorhabditis elegans. J Biol Chem. 2010; 285:39536-39543. Download PDF
  49. Severance S, Rajagopal A, Rao AU, Cerqueira GC, Mitreva M, El-Sayed NM, Krause M and Hamza I. Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. PLoS Genetics 2010;6:e1001044. Download PDF
  50. Schultz I, Chen C, Paw B and Hamza I. Iron and porphyrin trafficking in heme biogenesis. J. Biol. Chem. Jun 2010 (Epub). Download PDF
  51. Ihrig J, Hausmann A, Hain A, Richter N, Hamza I, Lill R and Mühlenhoff U. Iron regulation through the back door: Iron-dependent metabolite levels contribute to the transcriptional adaptation to iron deprivation in S. cerevisiae. Eukaryot Cell. 2010; 9:460-471 Download PDF
  52. Severance S and Hamza I. Trafficking of Heme and Porphyrins in Metazoa. Chem. Rev. 2009; 109:4596-4616. Download PDF
  53. Wu B, Novelli J, Foster J, Vaisvila R, Conway L, Ingram J, Ganatra M, Rao AU, Hamza I, Slatko B. The Heme Biosynthetic Pathway of the Obligate Wolbachia Endosymbiont of Brugia malayi as a Potential Anti-filarial Drug Target. PLoS Negl Trop Dis. 2009 3:e475. Download PDF
  54. Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M and Hamza I. Heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature 2008; 453: 1127-1131 Download PDF
    Highlighted by United Press International, Worms help in iron deficiency research
  55. Nass R and Hamza I. The Nematode C. elegans as an Animal Model to Explore Toxicology In Vivo: Solid and Axenic Growth Culture Conditions and Compound Exposure Parameters. In: Current Protocols in Toxicology Eds. Bus, JS, Costa LG, Hodgson E, Lawrence DA and Reed DJ. John Wiley & Sons, Inc., 2007; Unit 1.9 1.9.1-1.9.17. Download PDF
  56. Hamza I. Intracellular Trafficking of Porphyrins. ACS Chem. Biol. 2006;1: 627–629 Download PDF
  57. Held MR, Bungiro RD, Harrison LM, Hamza I and Cappello M. Dietary iron content mediates hookworm pathogenesis in vivo. Infect Immun. 2006;74:289-295 Download PDF.
    Highlighted in Science magazine
  58. Rao A, Carta L, Lesuisse E and Hamza I. Lack of Heme Synthesis in a Free-Living Eukaryote. Proc Natl Acad Sci. 2005; 102:4270-4275 Download PDF (Supporting Data)
  59. Hamza I, Prohaska JR and Gitlin. JD. Essential Role for Atox1 in the Copper-Mediated Intracellular Trafficking of the Menkes ATPase. Proc Natl Acad Sci. 2003; 100:1215-1220 Download PDF.
  60. Hamza I and Gitlin JD. Copper chaperones for cytochrome c oxidase and human disease. J Bioenerg Biomembr. 2002; 34:381-388 Download PDF.
  61. Hamza I and Gitlin JD. Hepatic Copper Transport. In: Molecular Pathogenesis of Cholestasis Ed. Trauner, M and Jansen P. Landes Bioscience, Austin, Texas 2002.
  62. Hamza I and Gitlin JD. Copper-transporting ATPases. In: The Encyclopedia of Molecular Medicine Ed. Creighton T. New York, John Wiley & Sons, 2002; 904-906.
  63. Hamza I, Faisst A, Prohaska JR, Chen J, Gruss P and Gitlin. JD. The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis. Proc Natl Acad Sci. 2001; 98: 6848-6852 Download PDF
    Editorial in PNAS by Andrews NC
    Highlighted in BBC World News
  64. Hamza I and Gitlin JD. Copper metabolism and the Liver. In: The Liver: Biology and Pathobiology. I Arias, Boyer, F Chisari, N Fausto, D Schachter and D Shafritz (eds) Williams and Wilkins, 2001; 331-343.
  65. Hamza I, Klomp LWJ, Gaedigk R, White RA and Gitlin JD. Structure, expression and chromosomal localization of the mouse Atox1 gene. Genomics 2000; 63:294-297 Download PDF.
  66. Hamza I, Qi Z, King ND and O’Brian MR. Fur-independent regulation of iron metabolism by Irr in Bradyrhizobium japonicum. Microbiology 2000; 146:669-676 Download PDF.
  67. Hamza I, Schaefer M, Klomp LWJ and Gitlin JD. Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. Proc Natl Acad Sci. 1999; 96:13363-13368 Download PDF.
  68. Qi Z, Hamza I and O’Brian MR. Heme is an effector molecule for iron-dependent degradation of the bacterial iron response regulator (Irr) protein. Proc Natl Acad Sci. 1999; 96:13056-13061 Download PDF.
  69. Hamza I, Hassett R and O’Brian MR. Identification of a functional fur gene in Bradyrhizobium japonicum. J Bacteriol. 1999; 181:5843-5846 Download PDF.
  70. Hamza I, Chauhan S, Hassett R and O’Brian MR. The bacterial Irr protein is required for coordination of heme biosynthesis with iron availability. J Biol Chem. 1998; 273:21669-21674 Download PDF.

Publications

Selected Publications

Google Scholar
NCBI Bibliography

Key publications

2019

Hemozoin produced by mammals confers heme tolerance.

[1][2]Pek RH, Yuan X, Rietzschel N, Zhang J, Jackson LK, Nishibori E, Ribeiro A, Simmons WR, Jagadeesh J, Sugimoto H, Alam MZ, Garrett LJ, Haldar M, Ralle M, Phillips J, Bodine D, Hamza I.

  • eLife, 2019; 8:e49503 (eLife Digest).

2017

Inter-organ signaling by HRG-7 promotes systemic heme homeostasis.

[3][4]Sinclair J, Pinter K, Samuel T, Beardsley S, Yuan X, Zhang J, Meng K, Yun S, Krause M, and Hamza I.

  • Nature Cell Biol. 2017;19:799-807.

2016

Regulation of intracellular heme trafficking revealed by subcellular reporters.

Yuan X, Rietzschel N, Kwon H, Nuno Da Silva ABW, Hanna DA, Phillips J, Raven E, Reddi AR and Hamza I.

  • Proc Natl Acad Sci, 2016; 113:E5144-5152.

2014

Control of metazoan heme homeostasis by a conserved multidrug resistance protein.

Korolnek T, Zhang J, Beardsley S, Scheffer GL, Hamza I.

  • Cell Metab. 2014;19:1008-1019.

2013

HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.

[5] White C, Yuan X, Schmidt PJ, Bresciani E, Samuel TK, Campagna D, Hall C, Bishop K, Calicchio ML, Lapierre A, Ward DM, Liu P, Fleming MD and Hamza I.

  • Cell Metab. 2013; 17: 261-270.

2011

An intercellular heme trafficking protein delivers maternal heme to the embryo during development in C. elegans.

[6] [7] [8] Chen C, Samuel TK, Sinclair J, Dailey H and Hamza I.

  • Cell. 2011; 145:720-731.

2008

Heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.

[9] [10] [11] Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M and Hamza I.

  • Nature 2008; 453: 1127-1131 (Epub Apr 16, 2008).

Selected reviews

  • Chambers IG, Willoughby MM, Hamza I, Reddi AR. One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers. Biochim Biophys Acta Mol Cell Res 2021, 1868(1):118881.
  • Soares MP and Hamza I. Macrophages and iron metabolism. Immunity 2016 Mar 15;44(3):492-504.
  • Korolnek T and Hamza I. Macrophages and iron trafficking at the birth and death of red cells. Blood. 2015 May 7;125(19):2893-2897. Epub 2015 Mar 16.
  • Hamza I and Dailey H. One ring to rule them all: Trafficking of heme and heme synthesis intermediates in eukaryotes. Biochim Biophys Acta- Molecular Cell Research. 2012;1823:1617-1632.
  • Severance S and Hamza I. Trafficking of Heme and Porphyrins in Metazoa. Chem. Rev. 2009; 109:4596-4616.

Iqbal Hamza, Ph.D. Professor

Dept. of Pediatrics, Center for Blood Oxygen Transport and Hemostasis (CBOTH)   
Dept. of Animal & Avian Sciences (Joint appointment with UMD)   
Biological Sciences Graduate Program (Member)

About Dr. Hamza

University of Maryland School of Medicine   
670 West Baltimore St
8175 HSFIII, CBOTH   
Baltimore, MD 21201   
Email: ihamza@som.umaryland.edu   
Phone: 410-706-4533

University of Maryland   
8127 Regents Drive
2125 Animal Sciences Center   
College Park, MD 20742   
Email: hamza@umd.edu   
Phone: 310-405-0649

[1] Highlighted in eLife Digest

[2] Highlighted in Press releases:
https://www.sciencedaily.com/releases/2019/10/191001110822.htm

[3] Highlighted in Press releases:
https://www.sciencedaily.com/releases/2017/06/170605121303.htm

[4] News & Views: Inter-organ regulation of haem homeostasis. Pitt JN and Kaeberlein M. Nat Cell Biol. 2017 Jun 29;19:756-758.

[5] Highlighted in Press releases:
http://www.sciencedaily.com/releases/2013/02/130205131752.htm

[6] Highlighted in Press releases:
http://www.sciencedaily.com/releases/2011/05/110526122909.htm
and
http://www.futurity.org/health-medicine/from-worms-clues-to-how-iron-moves/

[7] Recommended by the Faculty of 1000 Biology:
http://f1000.com/11215956
; F=6

[8] Research Highlight: Intercellular trafficking: Heme to go. Nat Chem Biol 2011; 7:496–497

[9] Modern Marvels: Iron, History Channel, Aug 14, 2008

[10] Highlighted by United Press International, Worms help in iron deficiency research, April 16, 2008:
http://www.sciencedaily.com/releases/2008/04/080416140912.htm

[11] Recommended by the Faculty of 1000 Biology:
http://f1000.com/1105036
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